Two fully staffed research grade fMRI facilities are available at UCI for brain imaging. These are: 1.5T Research System: A Picker Eclipse MR Imaging system dedicated to research with 27 mT/m whole-body gradients with 72 mT/msec gradient rise time is available for proposed studies. The system has multi and single shot EPI imaging capability as well as the necessary software and hardware for multinuclear spectroscopy. The system that is housed at the UCI Health Sciences Research Imaging Center is used for human and animal research studies. A new 3T magnet will go online in mid-2006 and will replace the 1.5T system. 4.0T MR Imaging/Spectroscopy System: A new 4 Tesla whole body MR system is available at the HS Research Imaging Center for human and animal studies. The system has a clear bore size of 90 cm and initially will have head access actively shielded gradient coils with 27 mT/m field strength for echo planar studies. Various rf coils including multi-frequency head and surface coils will be available. We have plans for building surface gradient coils for imaging other parts of the human body including sections of the spine with high resolution. Additionally, we will also acquire a body gradient coil for imaging the whole body. The system uses a Picker console for data acquisition that could be used for multinuclear spectroscopy and various MR imaging techniques up to 300 MHz. The initial configuration of the 4 Tesla system will enable us to perform echo planar imaging with a time resolution of down to 64 milliseconds and a spatial resolution of 128X128 which will be used mainly for functional MRI and dynamic contrast enhanced MRI. In addition to normal MR imaging with a resolution up to 1024X1024, we will also be able to perform in vivo spectroscopy of important nuclei such as H-1, C-13, F-19, and P-31.